1. NSAID-associated cardiovascular risk. NSAID use can increase your risk for certain cardiac complications, such as stroke and heart attack. These risks are elevated with long-term NSAID use, those with a history of cardiac disease, and older age. In one study, a cohort of almost 450,000 patients was analyzed. Voltaren may interact with antidepressants, blood thinners, cyclosporine, isoniazid, lithium, methotrexate, pronbenecid, rifampin, secobarbital, sertraline, sulfamethoxazole, teniposide, zafirlukast, diuretics (water pills), steroids, antifungal medications, aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs), cholesterol-lowering AN ALTERNATIVE TO PILLS, Voltaren is a nonsteroidal anti-inflammatory gel. DICLOFENAC SODIUM TOPICAL GEL PENETRATES DEEP to attack arthritis pain at the source. ARTHRITIS PAIN RELIEF in seven days. Apply on up to two joints for hand, ankle, or foot pain relief. Now FDA approved for over the counter. “The use of topical NSAIDs is not considered to increase the risk of bleeding” (Pharmacy Times, Dec. 21, 2017). Learn More: We discuss the pros and cons of topical diclofenac ( Voltaren Gel ) as well as salsalate and nondrug approaches in our eGuide to Alternatives for Arthritis . Voltaren is a nonsteroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and other inflammatory conditions. Like all medications, Voltaren can cause some side effects and these side effects are listed for both the topical cream and the pill for that is Photo orders. Treat joint pain safely with Voltaren topical arthritis pain relief gel, containing diclofenac, which combines the properties of an arthritis cream and a gel in a non-greasy formula called Emulgel. Voltaren contains the nonsteroidal anti-inflammatory drug diclofenac, which helps reduce pain associated with osteoarthritis and other ABS6p1.